Study of viscoelastic, sorption and mucoadhesive properties of selected polymer blends for biomedical applications

Oral mucoadhesive dosage formulations reveal numerous advantages they offer, like easy application, discrete handling and no need to swallow the drug product. Nevertheless, in order ensure correct performance of these preparations, must show suitable physicochemical properties, such as sorption wetting, viscosity adhesion mucous membrane. In this study, properties selected polymers their blends composed acrylic acid (Carbopol 974P NF, Noveon AA-1), cellulose derivatives (HEC, HPMC) film-forming polymer (Kollidon VA 64) were examined. The tested have been analyzed by techniques, flow rheometry, oscillatory rheometry liquid penetration method. Moreover, strength investigated was measured with use a texture analyzer. tests shown that anionic nonionic significantly worse adhesive than discs containing only Carbopol NF or AA-1.